Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites
نویسندگان
چکیده
منابع مشابه
Evidence for Correlation of Fragile Sites and Chromosomal Breakpoints in Carriers of Constitutional Balanced Chromosomal Rearrangements
A molecular cytogenetic study of 251 cases with balanced chromosomal rearrangements detected due to infertility of unclear origin or in prenatal diagnostics with a later normal outcome was done. Balanced translocations (127 cases), inversions (105 cases), insertions (three cases), balanced complex rearrangements (four cases), or derivative chromosomes leading to no imbalance (12 cases), were st...
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I T IS NOW WELL established that human tumors, particularly leukemias and lymphomas, are characterized by nonrandom chromosomal abnormalities. During the past 2 years, a number of proto-oncogenes and transforming genes have been mapped to the chromosomal breakpoints involved in the specific structural rearrangements. Experimental evidence obtained recently suggests that the genes located at the...
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DNA has the ability to form a variety of secondary structures that can interfere with normal cellular processes, and many of these structures have been associated with neurological diseases and cancer. Secondary structure-forming sequences are often found at chromosomal fragile sites, which are hotspots for sister chromatid exchange, chromosomal translocations, and deletions. Structures formed ...
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Cytogenetic imbalance in the newborn is a frequent cause of mental retardation and birth defects. Although aneuploidy accounts for the majority of imbalance, structural aberrations contribute to a significant fraction of recognized chromosomal anomalies. This review describes the major classes of constitutional, structural cytogenetic abnormalities and recent studies that explore the molecular ...
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Many cancers exhibit chromosomal rearrangements. These rearrangements can be simple with a single balanced fusion preserving the proper complement of genetic information or they can be complex with one or more fusions that distort this balance. A range of technological advances has improved our ability to detect and understand these rearrangements leading to speculation of causal mechanisms inc...
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ژورنال
عنوان ژورنال: Open Journal of Genetics
سال: 2013
ISSN: 2162-4453,2162-4461
DOI: 10.4236/ojgen.2013.32a3002